Ioannidis JPA. How to make more published research true. PLoS Medicine 2014;11(10):e1001747
Currently, many published research findings are false or exaggerated, and an estimated 85% of research resources are wasted. To improve the credibility and efficiency of scientific research, some practices may help increase the proportion of true research findings. They are: adoption of large-scale collaborative research; replication culture; registration; sharing; reproducibility practices; better statistical methods; standardization of definitions and analyses; more appropriate statistical thresholds; and improvement in study design standards, peer review, reporting and dissemination of research, and training of the scientific workforce.