Wednesday, March 22, 2017

B - Comparison of primary outcomes in protocols

Perlmutter A, Tran VT, Dechartres A, et al. Comparison of primary outcomes in protocols, public clinical-trial registries and publications: the example of oncology trials. Annals of Oncology 2016;mdw682
(doi: 10.1093/annonc/mdw682)

In oncology trials, primary outcome descriptions in ClinicalTrials.gov are often of low quality and may not reflect what is in the protocol, thus limiting the detection of modifications between planned and published outcomes. The authors compared primary outcomes in protocols, ClinicalTrials.gov and publications of oncology trials and evaluated the use of ClinicalTrials.gov as compared with protocols in detecting discrepancies between planned and published outcomes.
https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mdw682

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