Begley CG. Six red flags for suspect work. Nature 2013;497:433-434
According to many researchers the majority of preclinical cancer papers in top-ranking journals could not be reproduced, even by the original investigators. The author presents six questions that every author, editor, reviewer and reader should ask themselves when evaluating a research paper. They are: Were experiments performed blinded? Were basic experiments repeated? Were all the results presented? Were there positive and negative controls? Were reagents validated? and Were statistical tests appropriate? Each question is here analyzed.