Macleod M. Why animal research needs to improve. Nature 2011;477:511
Scant attention is usually given by authors, reviewers, and editors to the basic aspects related to the design of experiments, that use animals to model human diseases. In the face of pressures to reduce the number of animals used, researchers often do studies that are too small to detect a significant effect, and also tend to publish only positive results. Then, rules need to be changed: if publication in high-impact journals continues to be a yardstick, then the review process must do much more to assess bias.